Gluten-Free - The finished product contains no detectable gluten*

Vegan - The product is made without ingredients produced by or derived from animals

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Potency, Purity and Identity

*USA FDA classifies gluten-free as a finished product containing less than 20PPM gluten

Black Cohosh Root Extract
Black cohosh is a perennial, shrub-like plant, native to the eastern deciduous forests of North America. Traditionally, Black Cohosh was used to provide relief from menstrual cramps. It is used commonly as a remedy for hot flashes associated with menopause, and PMS. The precise mechanism of action is unknown; although, the triterpene glycosides are considered the active constituents along with the isoflavones, alkaloids and phenolic acids. Black Cohosh may help alleviate mild symptoms of menopause.

Soy Extract
Soy extract contains isoflavones in the form of phytoestrogens. Phytoestrogens are nonsteriodal compounds that come from plants.. Soy isoflavones include three main isoflavones, which are the aglycones genistein, daidzein and glycitein. Soy may be linked to alleviating mild menopausal symptoms and beneficial in promoting bone health.

Dong Quai Root Extract
Dong quai has been used in traditional Chinese and Native American medicine for thousands of years. The plant is related to both parsley and celery; its health properties come from the root. Dong quai is often referred to as the female ginseng because of its homeostatic effects during menstruation. Its most common use is to manage mild cramps and pain during menstruation as well as to alleviate some of the mild symptoms of menopause such as hot flashes. The specific mechanism of action is unknown; although, coumarin, ferulic acid and ligustilide appear to be the active constituents of the dong quai root. Coumarin aids in promoting normal blood flow, while the ferulic acid and ligustilide promote normal muscle relaxation. Dong quai is not a replacement for estrogen (although, some studies have shown that it has a similar effect as isoflavones) nor does it have any hormone-like effects on the body.

Wild Yam Powder
Wild Yam is a member of the Dioscorea family, which also includes the potato. The family is named for Dioscorides, who was the first-century Greek physician whose botanical writings were the standard for more than one thousand years. The dried roots are the health-promoting part of the plant. Wild yam has been historically used for mild symptoms associated with menstruation and menopause, including cramping, hot flashes and occasional fatigue. It is native to North America, but the plant can be cultivated in tropical, subtropical and temperate regions all around the world. Wild yam helps to regulate menstruation and menopause.

Chasteberry  Extract
Chasteberry extract or Vitex, is a shrub native to the Mediterranean and Central Asia, but can also be found around the United States. It is generally used in dietary supplements for mild symptoms of PMS and menopause. The flavonoids casticin, isovitexin and orientin are the main constituents of chasteberry extract. It is often used to promote a healthy menstrual cycle.

Horsetail Extract
Horsetail (Equisetum arvense), also known as Peterwort, Dutch rushes, Shave-grass and Bottlebrush, is named from the bristly appearance of its jointed stems. The plant is found throughout the northern hemisphere, and only the stems exhibit beneficial health-related properties. It has the ability to draw excess water from the body. Horsetail is a natural source of silicon, iron and sodium, and also contains high amounts of calcium, chromium, crude fiber, magnesium, potassium, selenium and vitamin A. Horsetail is an excellent source of silicic acid, which contributes to its health benefits. Horsetail has  been shown to be helpful with mild symptoms of PMS and menopause.

Red Clover Extract
Red clover, like soy, contains high levels of isoflavones. Red clover has been shown to help alleviate hot flashes associated with menopause. Red Clover is a small perennial herb with red or white flowers. It is native to Europe, central Asia, and northern Africa, but is also naturalized in many other parts of the world. Only the flowers are used in health supplements. It can be found as a dried herb, in tablets or capsules, and in alcohol solutions.

Valerian  Extract
Valerian Root (Valerian officinalis) produces bright pink to white flowers, and grows 20 to 40 inches tall. It is native to Europe and temperate regions of Asia, and is cultivated in Europe, Japan and the United States. The Ancient Greek physician Galen referred to valerian as “Phu,” which is an expression of disgust at the plants smell. It was given the name all-heal in medieval times due to its natural healing properties. It is usually prepared as a tea, taken in capsule or tablet form, or used to make a bath additive. Valerian Root is commonly used as a natural sleep aid, but it is also used for mild symptoms associated with premenstrual syndrome and menopause. Clinical trials have shown that extracts of the root have a sleep-inducing effect, which researchers believe stems from the herb’s tendency to boost levels of gamma-aminobutyric acid, a chemical messenger in the brain.

Passion Flower Extract
Passiflora, also known as the passion flower, can be used as an effective support for occasional sleep difficulty and restlessness. Passiflora is a perennial vine, which reaches 30 feet in length. It grows naturally from the southeastern United States to Brazil and Argentina, and is cultivated as a garden plant in Europe. The blossoms are considered symbolic of Christ’s Passion, because the central corona represents the Crown of Thorns, which accounts for its name. The health value is found in the above ground parts of the plants. Passiflora is available as an herb for tea, and is also an ingredient in some bath additives.

Red SageExtract
Sage (Salvia officinalis) has been used as a dietary supplement for years. Sage is native to the Mediterranean region, but is now grown in all of Europe and North America. In the United States, sage is primarily used as a seasoning, but it has a long history of medicinal use abroad. The health value of sage resides in its crushed, dried leaves and the oil that is extracted from its flowers, leaves and stems. It has been used for a variety of purposes, including helping to control hot flashes. The herb acts specifically on the uterus to help alleviate mild adverse symptoms of PMS including cramps. It is also good for relieving excessive perspiration from hot flashes.

Puncture Vine Extract
Puncture vine is a perennial plant, commonly found in India and Africa. It has been commonly used in the Ayurvedic mixtures . It is reported to help support normal bodily function and promote optimal blood circulation. It’s active components include saponins.

Thiamin (Vitamin B1)
Thiamin plays an important role in carbohydrate metabolism and nerve function. Thiamin is required for a healthy nervous system and assists in the production of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). It is used in the manufacture of hydrochloric acid, and therefore plays a part in digestion and supports energy.

Pantothenic Acid (Vitamin B5)
Pantothenic acid (vitamin B5) is a water-soluble vitamin involved in the Kreb’s cycle of energy production and promotes the normal production of the neurotransmitter acetylcholine. When the nerve impulse originating in the brain arrives at the nerve ending, it releases a chemical called acetylcholine, which promotes brain health. Pantothenic acid works together with vitamin B1, vitamin B2, and vitamin B3 to support the body’s normal production of adenosine triphosphate (ATP), the fuel our body uses to function. Vitamin B5 also supports normal producing, transporting, and releasing of energy from fats.

Niacin (Vitamin B3)
Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. It is part of the vitamin B complex. Niacin assists in the functioning of the digestive system, skin and nerves. It is also important for the conversion of food to energy. Niacin (also known as vitamin B-3) is found in dairy products, poultry, fish, lean meats, nuts and eggs as well as legumes and enriched breads and cereals.

Riboflavin (Vitamin B2)
Vitamin B2 is a water-soluble vitamin that promotes the body’s ability to process amino acids and fats, activate vitamin B6 and folic acid, and support the normal conversion of carbohydrates into adenosine triphosphate (ATP), the fuel the body uses to function. Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a co-enzyme, working with other B vitamins. It promotes healthy blood and supports both the nervous system and normal human growth. It supports healthy growth of skin, nails and hair and plays a crucial role in turning food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Vitamin B2 supports the breakdown of fats. Vitamin B2 cannot be stored by the body except in insignificant amounts; thus, it must be replenished daily.

Vitamin B6
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. Vitamin B6 supports numerous metabolic pathways in the body. One specific function is that it supports the normal synthesis of neurotransmitters in the brain and peripheral nerve cells. B6 also promotes the normal production of glutathione, which supports detoxification. It supports the production and breakdown of many amino acids. Vitamin B6 supports the maintenance of healthy red and white blood cells. It works to promotes normal hemoglobin synthesis (hemoglobin is the protein portion of red blood cells which carries oxygen throughout the body).

Folic Acid
Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans and peas are the best sources as well as Brewer’s yeast, which supplies additional B-vitamins. Folic acid boosts the benefits of vitamin B12 supplementation. Folic acid supports the normal utilization of amino acids and proteins. Scientific studies have found that when working in tandem with vitamin B12, folic acid supports healthy cardiovascular and nervous systems. Folic acid is a vitamin that promotes normal cell replication and growth and supports the normal formation of building blocks of DNA, the body’s genetic information, and building blocks of RNA needed for protein synthesis in all cells.

Methylcobalamin (Vitamin B12 )
Methylcobalamin is one of the naturally-occurring forms of vitamin B12 found in the human body. The liver must convert cyanocobalamin, the form of B12 most commonly used in supplements, into methylcobalamin, before it can be properly utilized by the body.  Methylcobalamin is more effective than non-active forms of vitamin B12. Methylcobalamin also promotes the normal formation of SAMe (S-adenosylmethionine), a nutrient that positively impacts mood. Vitamin B12 is naturally found in animal products, especially organ meats, such as liver, with small amounts derived from peanuts and fermented soy products, such as miso and tempeh. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. It supports the maintenance of cells, especially those of the nervous system, bone marrow and intestinal tract. Vitamin B12 promotes normal homocysteine metabolism (homocysteine is an amino acid that is formed within the body). Normal homocysteine levels are important for maintaining cardiovascular health. Folate and B12, in their active coenzyme form, help to maintain healthy blood levels of homocysteine. Vitamin B12 itself is responsible for maintaining optimum energy levels as it plays a vital role in the Krebs energy cycle.

Vitamin E
The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Vitamin E is actually a family of related compounds called tocopherols and tocotrienols. The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It also promotes normal healing and is known to promote cardiovascular health. Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radical damage. Studies have shown that supplemental vitamin E is helpful in counteracting mild effects of PMS.

What is Menopause?
Menopause is the ceasing of the monthly female menstrual cycle. A woman is considered menopausal when she has been without a menstrual cycle for at least for one year. Common symptoms of menopause are emotional and physical changes, mood swings, sleeplessness, hot flashes and night sweats. Some women experience perimenopause prior to menopause.  This period of time can include many of the symptoms of menopause before menstruation stops. The most common symptoms that perimenopausal and menopausal women complain of are hot flashes, flushes and sweats; thirty three percent of these women seek medical attention for the ailments.

What are estrogens?
Estrogens are a group of steroid compounds that are named for their importance in the estrus cycle. They function as the primary female sex hormone. Estrogen is present in men and women, but is usually at significantly higher levels in women of reproductive age. Estrogen is mainly produced in the developing follicles in the ovaries, but some is also produced by secondary sources such as the liver, adrenal glands and breasts. The secondary sources are particularly important for post-menopausal women.

Estrogens function structurally to promote the formation of female secondary sex characteristics, stimulate endometrial growth, increase uterine growth, increasing vessel and skin maintenance and bone formation.

What causes menopause symptoms to occur?
Menopause symptoms are caused by the loss of estrogen. Unfortunately , not all menopause symptoms can be treated by estrogen.

What is hormone replacement therapy?
Hormone replacement therapy is a system of medical treatments for perimenopausal and postmenopausal women. It is based on the assumption that it may prevent discomfort and health problems caused by diminished estrogen hormones. Hormone replacement therapy involves a series of drugs designed to artificially boost hormone levels, using estrogens, progesterone or progestins, and sometimes testosterone. It is seen as a short-term relief from menopausal symptoms or as a longer-term treatment to reduce osteoporosis.

When does Menopause occur?
The average age of menopause in Hong Kong women is 51. Some women have menopause in their 40s while some women may still have regular menses at the age of 54.

What are some common non-hormonal supplements for menopause?
The most common non-hormonal or herbal supplements for menopause are black cohosh, evening primrose oil, red clover, a vitamin B complex and vitamin E.

What is PMS?
PMS, or premenstrual syndrome, has been associated with a deficiency or excess of hormones, stress, nutritional deficiencies and other nutritional or lifestyle factors. Symptoms that are commonly associated with PMS include increased levels of stress and body weight.

When does PMS occur?
PMS occurs prior to menstruation for up to two weeks.

How common is PMS?
The percentage of women who experience PMS varies widely. According to a study of 66 healthy female clerical workers in Hong Kong showed that 92% reported some symptoms during the premenstrual phase. They were more likely to experience premenstrual fatigue and pain and less likely to experience premenstrual negative affect.

Are there any foods that aggravate PMS symptoms?
Yes. Some foods have been shown to aggravate the symptoms of PMS, such as saturated fats, hydrogenated fats, refined sugar, salt, caffeine and alcohol.

How do I take Prime Feminene?
As a dietary supplement, take two tablets daily or as directed by the healthcare provider.

Are there any contraindications or warnings for Prime Feminene?
Yes. If you are currently using warfarin [Coumadin], other anti-platelet / anti-coagulant medications, consult your healthcare provider before using this product.  If you are currently using any prescription medication, have an ongoing medical condition, or if you are pregnant or breastfeeding, consult your healthcare provider before using this product.  If you are allergic to any of the ingredients in this product, do not use.

Is Prime Feminene Female Support Formula safe?
Prime Feminene Female Support Formula is safe and free of harmful agents. The product is made in the United States in FDA-inspected facilities using Good Manufacturing Practices. Customers can have confidence in the quality and safety of this product.

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